Pathology plays a vital role across all facets of medicine throughout our lives, from pre-conception to post mortem. Pathology is integral to the diagnosis of every cancer. It underpins every aspect of medicine, from diagnostic testing and monitoring of chronic diseases to cutting-edge genetic research and blood transfusion technologies. The high levels of sensitivity provided by molecular assays allows for the detection of very small tumours that are otherwise undetectable by other means, and will likely result in earlier diagnosis, improved patient care and better outcomes for survival.Pathology is the medical specialty concerned with the study of the nature and causes of diseases. Molecular Pathology includes the development of molecular and genetic approaches to the diagnosis and classification of human tumours and also to design and validate predictive biomarkers for prognosis of the disease, and susceptibility of developing certain cancers in individuals. As a result, molecular analysis is leading the way towards personalized medicine by allowing us to predict a patient’s response to certain anti-cancer therapy based on their own genetic make-up. Many diseases such as cancer are caused by mutations or alterations in the genetic code of a person, and identification of specific hallmark mutations allows clinicians to classify a disease and choose the appropriate treatment. It emphasizes the study and diagnosis of disease through the examination of molecules within organs, tissues or bodily fluids. Molecular Pathology is a relatively recent discipline that has achieved remarkable progress over the past decade. The principal aim of an autopsy or post-mortem examination is to determine the cause of death, the state of health of the person before they died, and whether any medical diagnosis and treatment before death was appropriate. Prior to viewing the tissue under a microscope, slides processed by chemical fixation or frozen section are either stained with chemicals or antibodies to reveal cellular components.Īutopsy is a highly specialized surgical procedure that is performed by a pathologist and consists of a thorough examination of a corpse to determine the cause and manner of death and to evaluate any disease or injury that may be present. Frozen section processing involves freezing the tissue and generating thin frozen slices of the specimen which are mounted onto glass slides. Histological sections of tissue are processed for microscopic viewing using either chemical fixation or frozen section. Surgical pathology involves macroscopic (gross) and microscopic (histologic) tissue analysis where the molecular properties of tissue samples are assessed by immunohistochemistry or other laboratory tests. Surgically removed specimens are received from sources such as small biopsies of skin, core biopsies for the diagnosis of cancer, and the operating room where tumours are removed. Surgical Pathology is the most significant and time consuming branch of pathology with a primary focus on examining tissues with the naked eye or under a microscope for definitive diagnosis of disease. Our Graduate Studies Program trains candidates in laboratory research on disease. Our research laboratories are focused on understanding the cellular abnormalities in disease, with the eventual goal of improving both diagnosis and treatment. Areas of study include cellular adaptation to injury, necrosis (death of living cells or tissues), inflammation, wound healing, and neoplasia (abnormal new growth of cells), as well as specific disorders of the individual organ systems. Pathology also includes the related scientific study of disease processes whereby the causes, mechanisms and extent of disease are examined. Our Residency Program trains candidates in the diagnosis of disease. The cellular pattern of tissue samples are observed under a microscope to help determine if a sample is cancerous or non-cancerous (benign). specialize in a wide range of diseases including cancer and the vast majority of cancer diagnoses are made by pathologists. Aspects of a bodily specimen that may be considered include its gross anatomical make up, appearance of the cells using immunological markers and chemical signatures, as well as genetic studies and gene markers. Clinical pathology involves the examination of surgically removed organs, tissues (biopsy samples), bodily fluids, and in some cases the whole body (autopsy). Pathology is a branch of medical science that is focused on the study and diagnosis of disease.
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